Cytotoxic T cell response to viral infection.
نویسندگان
چکیده
منابع مشابه
Hemagglutinin-specific cytotoxic T-cell response during influenza infection
Specific cytotoxic thymus-derived (T) lymphocytes were detected in the cervical lymph nodes and spleen during influenza infection of mice. The cytotoxic T cells can distinguish target cells infected with different influenza A subtypes. Infection with parent viruses and their recombinant progeny possessing the hemagglutinin of one parent and the neuraminidase of the other demonstrated that sign...
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word count: 249 (Abstract) + 150 (Importance) 17 Text word count: 5,493 18 $ This work was funded in part by grant R56 AI0181860 from the NIH to HR. JVI Accepted Manuscript Posted Online 4 February 2015 J. Virol. doi:10.1128/JVI.03474-14 Copyright © 2015, American Society for Microbiology. All Rights Reserved. on D ecem er 6, 2017 by gest http/jvi.asm .rg/ D ow nladed fom
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CD4 T cells with cytotoxic function were once thought to be an artifact due to long-term in vitro cultures but have in more recent years become accepted and reported in the literature in response to a number of viral infections. In this review, we focus on cytotoxic CD4 T cells in the context of human viral infections and in some infections that affect mice and non-human primates. We examine th...
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The transcription factor T-bet is critical for cytotoxic T lymphocyte (CTL) differentiation, but it is unclear how it operates in a graded manner in the formation of both terminal effector and memory precursor cells during viral infection. We find that, at high concentrations, T-bet induced expression of Zeb2 mRNA, which then triggered CTLs to adopt terminally differentiated states. ZEB2 and T-...
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OF DISSERTATION Submitted in Partial Fulfillment of the Requirements for the Degree of Doctor of Philosophy Computer Science The University of New Mexico Albuquerque, New Mexico
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ژورنال
عنوان ژورنال: Uirusu
سال: 1993
ISSN: 0042-6857,1884-3433
DOI: 10.2222/jsv.43.139